Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors
Abdulkadir Özkan, Hari K. Padmanabhan, Seth L. Shipman, Eiman Azim, Priyanka Kumar, Cameron Sadegh, A. Nazlı Başak, Jeffrey D. Macklis
This study generates corticospinal-like neurons from SOX6+/NG2+ cortical progenitors using a multi-component transcriptional construct, achieving high fidelity in morphology, molecular, transcriptomic, and electrophysiological characteristics.
eLife · Jan 27, 2026Peer-reviewedNeuroscience