Eiman Azim

Adaptive Charge Modulation Enables Focal, Selective Spinal Cord Stimulation

This study introduces Adaptive Charge Modulation (ACM) for spinal cord stimulation, achieving focal activation at deep tissue sites with reduced surface activation and muscle co-activation.

Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

This study generates corticospinal-like neurons from SOX6+/NG2+ cortical progenitors using a multi-component transcriptional construct, achieving high fidelity in morphology, molecular, transcriptomic, and electrophysiological characteristics.

The antiviral Interferon pathway drives astrocyte aging and motor decline

This study shows that antiviral type I interferons drive astrocyte aging and motor decline in aging, with implications for therapeutic intervention.

Cerebellar outputs for rapid directional refinement of forelimb movement

This study identifies two cerebellar populations in mice that drive forelimb movement toward or away from the body, revealing a subcortical circuit basis for directional refinement during movement.

Selective Targeting of a Defined Subpopulation of Corticospinal Neurons using a Novel Klhl14-Cre Mouse Line Enables Molecular and Anatomical Investigations through Development into Maturity

This study generates a Klhl14-Cre mouse line to selectively identify and investigate a specific subpopulation of corticospinal neurons during development and into maturity.

The spinal premotor network driving scratching flexor and extensor alternation

The paper investigates the dynamics of spinal CPG neurons in scratch reflex rhythmogenesis and develops a neuromechanical model to explain their interactions.

The Dorsal Column Nuclei Scale Mechanical Sensitivity in Naive and Neuropathic Pain States

This study identifies the role of the gracile nucleus in mediating tactile sensitivity and mechanical allodynia during neuropathic pain in mice.

Vocal learning-associated convergent evolution in mammalian proteins and regulatory elements

The paper identifies proteins and regulatory elements associated with vocal learning by analyzing bat neural activity and epigenomic data.

Large-scale capture of hidden fluorescent labels for training generalizable markerless motion capture models

The paper introduces GlowTrack, a method to generate large-scale training data for markerless motion capture, enabling generalizable deep learning models for animal behavior analysis.

Myomatrix arrays for high-definition muscle recording

The paper introduces Myomatrix arrays, a high-resolution electrode technology for recording muscle activity from motor units across species during natural behaviors.

Modulation of tactile feedback for the execution of dexterous movement

The paper identifies a circuit mechanism that modulates tactile feedback in mice, showing how inhibitory circuits in the brainstem cuneate nucleus influence hand movement.

Anipose: a toolkit for robust markerless 3D pose estimation

Anipose provides a toolkit for markerless 3D pose estimation using 2D video, enabling analysis of animal movement and motor control.