Mesoderm-Derived PDGFRA+ Cells Regulate the Emergence of Hematopoietic Stem Cells in the Dorsal Aorta
Vashe Chandrakanthan, Prunella Rorimpandey, Fabio Zanini, Diego Chacon Fajardo, Jake Olivier, Swapna Mahurkar Joshi, Young Chan Kang, Kathy Knezevic, Yizhou Huang, Qiao Qiao, Rema A. Oliver, Ashwin Unnikrishnan, Daniel R. Carter, Brendan Lee, Chris Brownlee, , John E. Pimanda
The paper shows that mesoderm-derived PDGFRA+ stromal cells in the AGM region support endothelial-to-hematopoietic transition and LT-HSC generation.
Nature Cell Biology · Jul 28, 2022Peer-reviewedDevelopmental Biology