The paper identifies FBXW11 as a negative regulator of radial glial expansion and neuronal maturation in human cerebral organoids through CRISPR screening and functional validation.

bioRxiv · Sep 9, 2026 · PreprintNeuroscience

Cell Type-Specific Regulation by a Heptad of Transcription Factors in Human Hematopoietic Stem and Progenitor Cells

Shruthi Subramanian, Julie A.I. Thoms, Yizhou Huang, Paola Cornejo‐Páramo, Forrest C. Koch, Sébastien Jacquelin, Sylvie Shen, Emma YanJun Song, Swapna Mahurkar Joshi, Chris Brownlee, Petter S. Woll, Diego Chacon Fajardo, Dominik Beck, David J. Curtis, Kenneth Yehson, , John E. Pimanda

The paper identifies cell-type-specific regulatory roles of a heptad of transcription factors in human hematopoietic stem and progenitor cells.

bioRxiv · Apr 18, 2023 · PreprintDevelopmental Biology

Rhometa: Population recombination rate estimation from metagenomic read datasets

Sidaswar Krishnan, Matthew Z. DeMaere, Dominik Beck, Martin D. Ostrowski, Justin Robert Seymour, Aaron E. Darling

Rhometa estimates population recombination rates from metagenomic read datasets using a composite likelihood approach, showing accuracy with 80 genomes and real experimental data.

PLoS Genetics · Mar 27, 2023Peer-reviewedBioinformatics

Mesoderm-Derived PDGFRA+ Cells Regulate the Emergence of Hematopoietic Stem Cells in the Dorsal Aorta

Vashe Chandrakanthan, Prunella Rorimpandey, Fabio Zanini, Diego Chacon Fajardo, Jake Olivier, Swapna Mahurkar Joshi, Young Chan Kang, Kathy Knezevic, Yizhou Huang, Qiao Qiao, Rema A. Oliver, Ashwin Unnikrishnan, Daniel R. Carter, Brendan Lee, Chris Brownlee, , John E. Pimanda

The paper shows that mesoderm-derived PDGFRA+ stromal cells in the AGM region support endothelial-to-hematopoietic transition and LT-HSC generation.

Nature Cell Biology · Jul 28, 2022Peer-reviewedDevelopmental Biology