This study distinguishes tissue-resident memory (TRM) and exhausted T (TEX) cells in tumors by analyzing their antigen reactivity, clonality, and functional outcomes.

bioRxiv · Jul 23, 2025 · PreprintImmunology

Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia

Shellaina J.V. Gordon, Florian Perner, Laura MacPherson, Katie A. Fennell, Daniela Vanessa Wenge, Wallace Bourgeois, Tabea Klaus, Thomas Plenge, Anelya Murat, Jelena Petrovic, Jakub Horvath, Joan Q. Cao, John D. Lapek, Sean A. Uryu, Jeffrey R. White, , Mark A. Dawson

The paper shows that inhibiting KAT6/KAT7 enhances Menin inhibitor efficacy and overcomes resistance in MLL-FP leukemia.

Cancer Discovery · Jun 19, 2025Peer-reviewedCancer Biology

CRISPR-ChIP delineates a Menin-dependent oncogenic DOT1L complex in MLL-leukaemia

Omer Gilan, Charles C. Bell, Laure Talarmain, Daniel Neville, Kathy Knezevic, Daniel Ferguson, Marion Boudes, Yih-Chih Chan, Chen Davidovich, Enid Y.N. Lam, Mark A. Dawson

The paper introduces CRISPR-ChIP to identify chromatin factors associated with histone modifications in MLL-leukaemia, revealing distinct DOT1L complexes with oncogenic and endogenous functions.

bioRxiv · Mar 17, 2023 · PreprintMolecular Biology

Mesoderm-Derived PDGFRA+ Cells Regulate the Emergence of Hematopoietic Stem Cells in the Dorsal Aorta

Vashe Chandrakanthan, Prunella Rorimpandey, Fabio Zanini, Diego Chacon Fajardo, Jake Olivier, Swapna Mahurkar Joshi, Young Chan Kang, Kathy Knezevic, Yizhou Huang, Qiao Qiao, Rema A. Oliver, Ashwin Unnikrishnan, Daniel R. Carter, Brendan Lee, Chris Brownlee, , John E. Pimanda

The paper shows that mesoderm-derived PDGFRA+ stromal cells in the AGM region support endothelial-to-hematopoietic transition and LT-HSC generation.

Nature Cell Biology · Jul 28, 2022Peer-reviewedDevelopmental Biology