Iterative Epitope Expansion Enables Structure-Guided de novoDesign of IgE-Binding Miniproteins Targeting the FcεRI Interface
Ido Calman, Hamed Shaykhalishahi, Puwanat Sangkhapreecha, Sharrol T. Bachas
This paper develops an iterative epitope-expansion strategy to design IgE-binding miniproteins targeting the FcεRI interface, improving affinity and validating structural models through experimental testing.
bioRxiv · Dec 27, 2025 · PreprintBioengineering