Immune Selection Pressure Contributes to Pancreatic Cancer Immune Evasion
R. Ajina, A. Zuo, S. Wang, M. Moussa, C. J. Cooper, Y. Shen, Q. R. Johnson, J. M. Parks, J. C. Smith, M. Catalfamo, E. J. Fertig, S. A. Jablonski, L. M. Weiner
This study shows immune selection pressure in pancreatic cancer drives myeloid mimicry and immune evasion, which can be counteracted by JAK/STAT pathway inhibition to enhance immunotherapy.
bioRxiv · Jun 15, 2020 · PreprintCancer Biology