Pathway engineering in yeast for synthesizing the complex polyketide bikaverin
Meng Zhao, Yu Zhao, Mingdong Yao, Hala A. Iqbal, Qi Hu, Hong Liu, Bin Qiao, Chun Li, Christine A. S. Skovbjerg, Jens Christian Froslev Nielsen, Jens Nielsen, Rasmus John Normand Frandsen, Ying‐Jin Yuan, Jef D. Boeke
This study engineers the biosynthesis of the polyketide bikaverin in yeast by enhancing enzyme expression and using enzyme fusion to increase yield.
Nature Communications · Dec 3, 2020Peer-reviewedSynthetic Biology