Chun Li

The paper identifies the evolutionary origins and reconstructs the biosynthetic pathway of gingerols using multi-omics approaches, enabling microbial production of 6-gingerol.

This study identifies UHRF1 as a host factor that restricts HCoV-229E infection by epigenetically silencing its receptor APN, with age-related UHRF1 decline linked to increased viral susceptibility.

The paper reconstructs a multi-route biosynthetic network for glabridin in yeast, showing increased robustness and productivity compared to single-route designs.

The paper demonstrates that DNA N6-adenine methylation (6mA) is transmitted semi-conservatively in Tetrahymena thermophila, with AMT1-dependent maintenance and AMT1-independent de novo methylation mechanisms.

This study engineers the biosynthesis of the polyketide bikaverin in yeast by enhancing enzyme expression and using enzyme fusion to increase yield.