Jens Christian Nielsen

Specificity-driven protein binder design with Odin-Multi

Odin-Multi is a binder design framework that optimizes sequences against multiple targets simultaneously, improving cross-reactivity and specificity compared to single-target methods.

De novo designed cyclic MC4R peptide agonist reduces food intake in mice

The paper designs a cyclic MC4R peptide agonist using deep learning and validates its efficacy in reducing food intake in mice.

Pathway engineering in yeast for synthesizing the complex polyketide bikaverin

This study engineers the biosynthesis of the polyketide bikaverin in yeast by enhancing enzyme expression and using enzyme fusion to increase yield.