Suppressing cortical glutamatergic neurons produces paradoxical interictal discharges and seizures
Shiqiang Wu, Qianwei Zhou, Jaehyeon Ryu, Ge Li, Aditya Iyer, Brian J. A. Gill, Hongtao Ma, Hui Fang, Catherine A. Schevon, Theodore H. Schwartz, Jyun-you Liou
The paper shows that suppressing cortical glutamatergic neurons can paradoxically cause seizures and interictal discharges in vivo.
bioRxiv · Oct 2, 2025 · PreprintNeuroscience