Jyun-you Liou

The paper introduces TrUDI, a three-photon microscopy system that improves imaging depth in the mouse brain to ~2 mm with enhanced fluorescence detection.

The paper shows that suppressing cortical glutamatergic neurons can paradoxically cause seizures and interictal discharges in vivo.

The paper shows that interictal epileptiform discharges (IEDs) are bidirectional traveling waves that follow the same path and direction as ictal discharges, suggesting they originate outside the seizure focus.

The paper develops a neural network model to simulate focal seizure dynamics, including initiation, propagation, termination, and progression, and identifies mechanisms underlying seizure patterns and synaptic plasticity.

The paper investigates how inhibitory control affects the spread of focal ictal activity in a rodent model, showing that localized inhibition defects can lead to both classical and epileptic network propagation.