Macrophages Lacking TSC2 have mTORC1-dependent GPNMB Augmentation Ameliorating Cardiac Ischemia-Reperfusion Injury
Mohammad Keykhaei, Navid Koleini, Mariam Meddeb, Masih Tajdini, Malihe Rezaee, Qiao Huang, Tegbir Panesar, Mark John Ranek, Luigi Adamo, David A. Kass
This study shows that macrophages with constitutive mTORC1 activation via TSC2 deletion reduce inflammation and improve cardiac function after ischemia-reperfusion injury by increasing GPNMB expression.
bioRxiv · May 29, 2025 · PreprintImmunology