Author

Mariam Meddeb

Johns Hopkins UniversityORCID 0000-0002-6922-1587Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

David A. KassiD· 3 shared Mohammad KeykhaeiiD· 3 shared Navid KoleiniiD· 3 shared Kavita SharmaiD· 2 shared Liang ZhaoiD· 2 shared Malihe RezaeeiD· 2 shared Tegbir Panesar· 2 shared Brian LiniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersMolecular Biology

David A. KassORCID

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3 papers

Recent·Most cited

Reduced Myocardial Serine Synthesis Impairs Functional, Metabolic, and Redox Adaptations to Cardiac Stress

Malihe Rezaee, Mohammad Keykhaei, Navid Koleini, Tegbir Panesar, Simiao Li, Nalini Salvekar, David J. Polhemus, Chengchen Hu, Mariam Meddeb, Liang Zhao, Kavita Sharma, Christopher J. Petucci, Nathaniel W. Snyder, Junichi Sadoshima, David A. Kass

This study shows that reduced myocardial serine synthesis impairs cardiac stress responses by disrupting redox balance, one-carbon metabolism, and amino acid homeostasis.

bioRxiv · Jun 2, 2026 · PreprintMolecular Biology

Macrophages Lacking TSC2 have mTORC1-dependent GPNMB Augmentation Ameliorating Cardiac Ischemia-Reperfusion Injury

Mohammad Keykhaei, Navid Koleini, Mariam Meddeb, Masih Tajdini, Malihe Rezaee, Qiao Huang, Tegbir Panesar, Mark John Ranek, Luigi Adamo, David A. Kass

This study shows that macrophages with constitutive mTORC1 activation via TSC2 deletion reduce inflammation and improve cardiac function after ischemia-reperfusion injury by increasing GPNMB expression.

bioRxiv · May 29, 2025 · PreprintImmunology

ATP Citrate Lyase Supports Cardiac Function and NAD+/NADH Balance And Is Depressed in Human Heart Failure

Mariam Meddeb, Navid Koleini, Seungho Jun, Mohammad Keykhaei, Farnaz Farshidfar, Liang Zhao, Seoyoung Kwon, Brian Lin, Gizem Keceli, Nazareno Paolocci, Virginia Shalkey Hahn, Kavita Sharma, Erika L. Pearce, David A. Kass

This study investigates the role of ATP citrate lyase (ACLY) in cardiac function and NAD+/NADH balance, finding it is reduced in heart failure and its inhibition impairs cardiac function and metabolism.

bioRxiv · Jun 9, 2024 · PreprintMolecular Biology