Reduced Myocardial Serine Synthesis Impairs Functional, Metabolic, and Redox Adaptations to Cardiac Stress
Malihe Rezaee, Mohammad Keykhaei, Navid Koleini, Tegbir Panesar, Simiao Li, Nalini Salvekar, David J. Polhemus, Chengchen Hu, Mariam Meddeb, Liang Zhao, Kavita Sharma, Christopher J. Petucci, Nathaniel W. Snyder, Junichi Sadoshima, David A. Kass
This study shows that reduced myocardial serine synthesis impairs cardiac stress responses by disrupting redox balance, one-carbon metabolism, and amino acid homeostasis.
bioRxiv · Jun 2, 2026 · PreprintMolecular Biology