Contractile function maintains cardiomyocyte differentiation and inhibits cell cycle activity
Lynn Devilée, Janice D. Reid, James Robert Krycer, Harley Robinson, Sean J. Humphrey, Chris Siu Yeung Chow, Mary Lor, Rebecca L. Fitzsimmons, Qing-Dong Wang, Michael Robert Doran, Enzo R. Porrello, Nathan J. Palpant, Simon Richard Foster, Richard J. Mills, James E. Hudson
The paper shows that inhibiting contractile function in cardiomyocytes reactivates the cell cycle, suggesting active contraction maintains differentiation and cell cycle arrest.
bioRxiv · Aug 19, 2025 · PreprintCell Biology