Harley Robinson

Alzheimer's Disease-Associated Proteomic Changes in Olfactory Stem Cells Show Pathway-Level Transcriptomic Overlap

This study identifies proteomic and transcriptomic changes in olfactory stem cells from AD and MCI patients, revealing pathway-level overlaps and potential biomarkers.

Monocyte Migration Emerges from a Divergent Chemokine Signaling Network

The paper maps the chemokine-stimulated signal transduction network in monocytic cells and shows that chemotaxis emerges from a divergent signaling network that can be inhibited to block cell migration.

Prenylation controls proliferation in human pluripotent stem cell-derived cardiomyocytes

This study identifies prenylation as a regulator of cardiomyocyte proliferation through multiple targets, suggesting its potential for cardiac regeneration.

Contractile function maintains cardiomyocyte differentiation and inhibits cell cycle activity

The paper shows that inhibiting contractile function in cardiomyocytes reactivates the cell cycle, suggesting active contraction maintains differentiation and cell cycle arrest.

Maturation of human cardiac organoids are required for disease modelling and drug discovery

This study shows that maturing human cardiac organoids enhances disease modeling and drug discovery by mimicking in vivo development and enabling therapeutic testing for DSP cardiomyopathy.

A transient modified mRNA encoding Myc and Cyclin T1 induces cardiac regeneration and improves cardiac function after myocardial injury

This study shows that modified mRNA encoding Myc and Cyclin T1 can induce cardiomyocyte proliferation and improve cardiac function after myocardial injury in mice.