Human fibrosarcoma cells selected for very-high doxorubicin resistance, acquire trabectedin and eribulin cross-resistance, remain sensitive to recombinant methioninase, and have increased c-MYC expression
Sei Morinaga, Qinghong Han, KOHEI MIZUTA, Byung Mo Kang, Michael Bouvet, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Hiroyuki Tsuchiya, Satoru Demura, Robert M. Hoffman
This study shows that doxorubicin-resistant fibrosarcoma cells are cross-resistant to trabectedin and eribulin but remain sensitive to recombinant methioninase, with increased c-MYC expression.
Frontiers in Oncology · Dec 8, 2025Peer-reviewedCancer Biology