BiochemistrybioRxivPreprint
The third-generation tetracycline, KBP-7072, exploits and reveals a new potential of the primary tetracycline binding pocket
Tatsuya Kaminishi, Andreas Schedlbauer, Borja Ochoa-Lizarralde…·Paola Fucini
This study determines the structure of KBP-7072 bound to the 30S ribosomal subunit, showing it inhibits protein synthesis by binding to the primary tetracycline site and interacting uniquely with the subunit.
DOI 10.1101/508218