AI-based Predictive Signaling Pathway Profiling in Cardiac Fibrosis Suggests a Novel Combinatorial Treatment Strategy
Bo Yang, Jie Chen, Qiongjie Mi, Jiuzhou Huo, Ningxin Gao, Xinhua Lin, Jeffery D. Molkentin, Qinghang Meng
The paper uses AI to analyze signaling pathways in cardiac fibrosis, identifying a dual-target treatment strategy with timed inhibition of JAK-STAT and TGF-β to reduce fibrosis without impairing acute scar formation.
bioRxiv · Dec 5, 2025 · PreprintCell Biology