Xinhua Lin

AI-based Predictive Signaling Pathway Profiling in Cardiac Fibrosis Suggests a Novel Combinatorial Treatment Strategy

The paper uses AI to analyze signaling pathways in cardiac fibrosis, identifying a dual-target treatment strategy with timed inhibition of JAK-STAT and TGF-β to reduce fibrosis without impairing acute scar formation.

ZNHIT1-dependent H2A.Z deposition at meiotic prophase I underlies pachytene gene expression and meiotic progression during male meiosis

This study identifies ZNHIT1's role in meiotic progression by regulating H2A.Z deposition and gene expression during pachytene in male meiosis.

Notch dimerization contributes to maintenance of intestinal homeostasis by a mechanism involving HDAC2.

The paper shows that Notch dimerization is crucial for intestinal homeostasis, with HDAC2 activity modulating Notch function in intestinal stem cells.

The unique function of Runx1 in skeletal muscle differentiation and regeneration is mediated by an ETS interaction domain

This study identifies the unique role of Runx1 in skeletal muscle differentiation and regeneration through its ETS interaction domain, distinguishing it from Runx2.