A Practical Framework for Constructing Population-Specific and Alternate-Contig-Aware Genome References: A case study of Vietnam
Trang T. H. Tran, Vinh C. Duong, Nam N. Nguyen, Tien M. Pham, Quang T. Vu, Mai Hoang Tran, Tham H. Hoang, Quan Hoang Nguyen, Nguyen Thuy Duong, Nam S. Vo
This paper introduces a framework for creating population-specific genome references using alternate-contig awareness, demonstrating improved variant calling in Vietnamese populations compared to GRCh38.
bioRxiv · Aug 27, 2026 · PreprintGenomics