Glymphatic function restored by α1-noradrenergic antagonism alleviates headache allodynia in mice
Adriana Della Pietra, Adisa Kuburas, Mathew Sevao, Tristen M. Castillo, Quinn Hanigan, Thomas L. Duong, Harold C. Flinn, Emilie H. Partridge, Murray A. Raskind, Jeffrey J. Iliff, Andrew F. Russo
This study shows that prazosin, an α1-noradrenergic antagonist, restores glymphatic function and reduces facial allodynia in mice with migraine-like symptoms.
bioRxiv · Apr 28, 2026 · PreprintNeuroscience