Jeffrey J. Iliff

Hormonal Modulation of Subjective Sleep Quality and Perivascular Space Volume Across the Menstrual Cycle: An Observational Dense-Sampling Study

This study examines how hormonal changes during the menstrual cycle and under oral contraceptive use affect sleep quality and perivascular space volume, finding that LH and FSH levels are associated with sleep quality and PVSV changes.

Aquaporin-4 mislocalization from astrocyte endfeet prolongs survival in a prion-cerebral amyloid angiopathy model

This study shows that reducing AQP4 function in a prion-CAA mouse model prolongs survival and reduces neuroinflammation without affecting prion spread.

Glymphatic function restored by α1-noradrenergic antagonism alleviates headache allodynia in mice

This study shows that prazosin, an α1-noradrenergic antagonist, restores glymphatic function and reduces facial allodynia in mice with migraine-like symptoms.

Biological sex and BMI influence the longitudinal evolution of adolescent and young adult MRI-visible perivascular spaces

This study examines how biological sex and BMI affect the longitudinal changes in MRI-visible perivascular spaces (MV-PVS) in adolescents and young adults.

Aquaporin-4 mis-localization slows glymphatic clearance of α-synuclein and promotes α-synuclein pathology and aggregate propagation

This study shows that AQP4 mis-localization impairs glymphatic clearance of α-synuclein and promotes its aggregation and spread in neurodegenerative diseases.

Preliminary cross-sectional investigations into the human glymphatic system using multiple novel non-contrast MRI methods.

The paper uses two non-contrast MRI methods to investigate the glymphatic system's response to sleep and aging in humans.

Interrogation of dynamic glucose-enhanced MRI and fluorescence-based imaging reveals a perturbed glymphatic network in Huntington disease

This study uses MRI and fluorescence imaging to show impaired glymphatic function in a mouse model of Huntington disease, suggesting it as a potential biomarker and therapeutic target.

Pulsation changes link to impaired glymphatic function in a mouse model of vascular cognitive impairment

This study shows that bilateral common carotid stenosis impairs glymphatic function and vascular pulsation in mice, contributing to cognitive decline in vascular cognitive impairment.

Sleep Dependent Changes of Lactate Concentration in Human Brain

This paper measures brain lactate levels during sleep-wake cycles in humans using MRS and PSG, finding significant reductions during sleep stages compared to wakefulness.

MRI-Visible Perivascular Space (PVS) Changes with Long-Duration Spaceflight

This study examines how spaceflight affects MRI-visible perivascular spaces (PVSs) in astronauts, finding that novice astronauts show increased PVS volume post-flight, while experienced astronauts show baseline correlations between flight days and PVS length.

Varying perivascular astroglial endfoot dimensions along the vascular tree maintain perivascular-interstitial flux through the cortical mantle

The paper characterizes astrocyte endfoot dimensions along the vascular tree in mice and shows that varying endfoot sizes maintain perivascular-interstitial fluid flux despite pressure changes.

Aquaporin-4 dependent glymphatic solute transport in rodent brain

This study confirms that AQP4 is essential for glymphatic fluid and solute transport in the rodent brain, as Aqp4 disruption reduces CSF influx and amyloid-beta efflux.