Lineage Memory and Convergent Adaptation Dictate the Single-Cell and Spatial Architecture of Brain Malignancies
Fei Wang, Xiaodong Pang, C Yang, R J Huang, Wenqian Cao, Yu Bai, Haohao Qiu, Juyi Zhang, Bixi Gao, Chao Ma, Yanbo Yang, S M Yang, Dengfeng Lu, Zhouqing Chen, Xiaoou Sun, Zhong Wang
This study constructs the largest single-cell atlas of brain malignancies, revealing lineage memory, convergent adaptation, and spatial architecture shaping tumor microenvironments and clinical outcomes.
bioRxiv · Jun 16, 2026 · PreprintCancer Biology