Yanbo Yang

The paper constructs a single-cell and spatial atlas of glioblastoma resistance, identifying a 'Spatial Resistance Triad' and demonstrating that targeting stromal components can overcome therapeutic resistance.

This study constructs the largest single-cell atlas of brain malignancies, revealing lineage memory, convergent adaptation, and spatial architecture shaping tumor microenvironments and clinical outcomes.

This study shows that synchrotron-based proton FLASH techniques preserve neurocognitive function in mice, with neuroprotection observed across different delivery methods and dose-rate metrics.

The paper investigates how Angubindin-1 disrupts the blood-tumor barrier by targeting Angulin-1/LSR, enhancing drug permeability and reducing glioma progression.

This study shows that combining SHP2 inhibition with BRAF inhibitors overcomes resistance in BRAF V600E-driven gliomas by suppressing RAS/ERK signaling and preventing tumor growth.