A Single-Cell and Spatial Atlas of MVP-PAN Evolution Reveals a Desmoplastic Dependency to Overcome Glioblastoma Resistance
Fang Wang, Xin Wu, Guozheng Zhao, Run Huang, Chen Yang, Yu Bai, Wenqian Cao, Yue Lu, Yue Lu, Haohao Qiu, Hongyi Ling, Dengfeng Lu, Youjia Qiu, Juyi Zhang, Bixi Gao, , Zhong Wang
The paper constructs a single-cell and spatial atlas of glioblastoma resistance, identifying a 'Spatial Resistance Triad' and demonstrating that targeting stromal components can overcome therapeutic resistance.
bioRxiv · Jun 17, 2026 · PreprintCancer Biology