Xiaoou Sun

The paper reports cryo-EM structures of melanocortin receptors bound to endogenous inverse agonists, revealing mechanisms of inverse agonism and subtype selectivity.

This study constructs the largest single-cell atlas of brain malignancies, revealing lineage memory, convergent adaptation, and spatial architecture shaping tumor microenvironments and clinical outcomes.

The paper stabilizes GPCRs in specific conformations using a fusion protein and screens nanobodies to identify conformation-specific binders.

This paper identifies atazanavir as a pan-positive allosteric modulator that activates multiple Family A GPCRs and sustains G protein signaling through non-canonical mechanisms.

This study determines the structure of a GPCR-G protein-β-arrestin complex stabilized by an allosteric modulator, showing a novel binding mode that allows coexistence with G protein signaling.