Therapeutically targetable Th17-derived miR-721 drives autoimmune myocarditis through PPARγ repression
Ignacio Ruiz‐Fernández, Raquel Sánchez‐Díaz, Rafael Blanco-Domínguez, Enrique Ortega‐Sollero, R Ortego-Molto, Daniela Quiroga-Ortiz, Hortensia de la Fuente, José Martínez‐González, Luis Jesús Jiménez‐Borreguero, Beatriz López‐Melgar, Fernando Rivero, Fernándo Alfonso, Francisco Sánchez‐Madrid, Mercedes Ricote, Pilar Martín
This study identifies miR-721 as a Th17-derived miRNA that drives autoimmune myocarditis by repressing PPARγ, offering a therapeutic target for treatment.
bioRxiv · Mar 26, 2026 · PreprintImmunology