Author

Enrique Ortega‐Sollero

Spanish National Centre for Cardiovascular ResearchORCID 0000-0002-1489-9294Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Aishwarya Nene· 1 shared Alan GutierreziD· 1 shared Amir Z. MuniriD· 1 shared Anya C. Shyani· 1 shared Beatriz López‐MelgariD· 1 shared C M KrawieciD· 1 shared Daniela Quiroga-Ortiz· 1 shared Eva Rodriguez· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Aishwarya Nene

Mutual co-authors in cluster

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2 papers

Recent·Most cited

A CD4-CD8 T-cell circuit converts cardiac inflammation into tissue injury

Amir Z. Munir, Alan Gutierrez, C M Krawiec, Riad Ghandour, Richard A. Baylis, Anya C. Shyani, Eva Rodriguez, Enrique Ortega‐Sollero, Aishwarya Nene, Javid J. Moslehi

This study shows that CD4-CD8 T-cell interactions are necessary for cardiac injury, as perforin-dependent cytotoxicity drives tissue damage despite ongoing inflammation.

bioRxiv · Sep 24, 2026 · PreprintImmunology

Therapeutically targetable Th17-derived miR-721 drives autoimmune myocarditis through PPARγ repression

Ignacio Ruiz‐Fernández, Raquel Sánchez‐Díaz, Rafael Blanco-Domínguez, Enrique Ortega‐Sollero, R Ortego-Molto, Daniela Quiroga-Ortiz, Hortensia de la Fuente, José Martínez‐González, Luis Jesús Jiménez‐Borreguero, Beatriz López‐Melgar, Fernando Rivero, Fernándo Alfonso, Francisco Sánchez‐Madrid, Mercedes Ricote, Pilar Martín

This study identifies miR-721 as a Th17-derived miRNA that drives autoimmune myocarditis by repressing PPARγ, offering a therapeutic target for treatment.

bioRxiv · Mar 26, 2026 · PreprintImmunology