Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint
L. H. Pearl, N. Bigot, M. Day, R. A. Baldock, F. Z. Watts, A. Oliver
This study identifies a phosphorylation-dependent interaction between 53BP1 and TOPBP1 that is critical for the G1 DNA damage checkpoint by recruiting ATR and CHK1 to damage foci.
bioRxiv · Jan 2, 2019Cell Biology