Distinct stimulatory mechanisms regulate the catalytic activity of Polycomb Repressive Complex 2 (PRC2)
C.-H. Lee, M. Holder, D. Grau, R. Saldana-Meyer, R. A. Ganai, J. Zhang, M. Wang, M.-W. Dobenecker, D. Reinberg, K.-J. Armache
The paper shows that EZH1 and EZH2, two catalytic subunits of PRC2, are differentially activated to regulate H3K27 methylation, with AEBP2 adding additional stimulation.
bioRxiv · Nov 3, 2017Biochemistry