Author

D. Reinberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:ChIP-seq· 4 Research Focus:chromatin & epigenetic regulation· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

N. Descostes· 3 shared C.-H. Lee· 2 shared G. LeRoy· 2 shared J.-R. Yu· 2 shared R. Saldana-Meyer· 2 shared Y. Jin· 2 shared A. D. Hamilton· 1 shared A. Leibholz· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersPhysiology

N. Descostes

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Insulin signaling and extended longevity in ants

H. Yan, C. Opachaloemphan, F. Carmona-Aldana, G. Mancini, J. Mlejnek, N. Descostes, B. Sieriebriennikov, A. Leibholz, X. Zhou, L. Ding, M. Traficante, C. Desplan, D. Reinberg

The paper investigates how insulin signaling and anti-insulin mechanisms in ants link reproduction to extended longevity through gene expression analysis in different castes.

bioRxiv · Jun 25, 2022 · PreprintPhysiology

NRF1 Association with AUTS2-Polycomb Mediates Specific Gene Activation in the Brain

S. Liu, K. A. Aldinger, C. V. Cheng, T. Kiyama, M. Dave, H. K. McNamara, S. G. Caraffi, I. Ivanovski, E. Errichiello, C. Zweier, O. Zuffardi, M. Schneider, A. S. Papavasiliou, M. S. Perry, M. T. Cho, , D. Reinberg

The paper identifies NRF1's role in PRC1.3 recruitment to chromatin and shows AUTS2 mutations disrupt gene regulation and motor neuron differentiation.

bioRxiv · Mar 30, 2021Biochemistry

The H3K36me2 writer-reader dependency in H3K27M-DIPG

J.-R. Yu, G. LeRoy, D. Bready, J. D. Frenster, R. Saldana-Meyer, Y. Jin, N. Descostes, J. M. Stafford, D. G. Placantonakis, D. Reinberg

This study identifies NSD1/2 as key writers and LEDGF/HDGF2 as readers of H3K36me2 in H3K27M-DIPG, showing their role in tumor proliferation and suggesting therapeutic targeting.

bioRxiv · Jan 6, 2021Cancer Biology

A CRISPR Screen Identifies Myc-associated Zinc Finger Protein (MAZ) as an Insulator Functioning at CTCF boundaries in Hox Clusters

H. Ortabozkoyun Kara, P.-Y. Huang, H. Cho, V. Narendra, G. LeRoy, J. A. Skok, A. Tsirigos, E. O. Mazzoni, D. Reinberg

The paper identifies MAZ as an insulator functioning at CTCF boundaries in Hox clusters, contributing to genomic architecture during differentiation.

bioRxiv · Aug 25, 2020Biochemistry

Active and repressed chromatin domains exhibit distinct nucleosome segregation during DNA replication

T. Escobar, O. Oksuz, N. Descostes, R. Bonasio, D. Reinberg

The paper investigates nucleosome inheritance during DNA replication in mouse embryonic stem cells, finding that repressed chromatin domains retain parental nucleosomes while active domains do not.

bioRxiv · Jan 17, 2019Biochemistry

Distinct stimulatory mechanisms regulate the catalytic activity of Polycomb Repressive Complex 2 (PRC2)

C.-H. Lee, M. Holder, D. Grau, R. Saldana-Meyer, R. A. Ganai, J. Zhang, M. Wang, M.-W. Dobenecker, D. Reinberg, K.-J. Armache

The paper shows that EZH1 and EZH2, two catalytic subunits of PRC2, are differentially activated to regulate H3K27 methylation, with AEBP2 adding additional stimulation.

bioRxiv · Nov 3, 2017Biochemistry

Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin

C.-H. Lee, J.-R. Yu, S. Kumar, Y. Jin, S. Kaneko, A. D. Hamilton, D. Reinberg

This study shows that PRC2 activity is controlled by allosteric activation, independent of its chromatin recruitment, and identifies vulnerabilities in PRC2-addicted cancers.

bioRxiv · Oct 28, 2017Biochemistry