Author

K.-J. Armache

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 6 Approach:experimental assay· 6 Assay:ChIP-seq· 5 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. Lu· 3 shared P. De Ioannes· 3 shared R. Lee· 3 shared S. Abini-Agbomson· 3 shared D. Grau· 2 shared E. Nudler· 2 shared H. Taylor· 2 shared K. Gretarsson· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiochemistry

C. Lu

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Author profile →

6 papers

Recent·Most cited

Cancer-associated DNA Hypermethylation of Polycomb Targets Requires DNMT3A Dual Recognition of Histone H2AK119 Ubiquitination and the Nucleosome Acidic Patch

K. H. Gretarsson, S. Abini-Agbomson, S. Gloor, D. N. Weinberg, J. L. McCuiston, V. U. N. S. Kumary, A. Hickman, V. Sahu, R. Lee, X. Xu, N. Lipieta, S. Flashner, O. A. Adeleke, I. K. Popova, H. Taylor, , C. Lu

The paper identifies a critical binding interface in DNMT3A1 that facilitates DNA hypermethylation at Polycomb target genes by recognizing H2AK119Ub and the nucleosome acidic patch.

bioRxiv · Mar 18, 2024Cancer Biology

Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1

S. Abini-Agbomson, K. Gretarsson, R. M. Shih, L. Hsieh, T. Lou, P. De Ioannes, N. Vasilyev, R. Lee, M. Wang, M. Simon, J.-P. Armache, E. Nudler, G. Narlikar, S. Liu, C. Lu, K.-J. Armache

This study characterizes the catalytic and non-catalytic mechanisms of SUV420H1 by determining cryo-EM structures and showing its role in DNA accessibility and chromatin condensation.

bioRxiv · Mar 17, 2023Biochemistry

Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1

J. F. Thomas, M. I. Valencia-Sanchez, S. Tamburri, S. L. Gloor, S. Rustichelli, V. Godinez-Lopez, P. De Ioannes, R. Lee, S. Abini-Agbomson, K. Gretarsson, J. M. Burg, A. R. Hickman, L. Sun, S. Gopinath, H. Taylor, , K.-J. Armache

This study reveals the molecular mechanism of nucleosomal H2AK119Ub deubiquitination by human BAP1/ASXL1 and explains how cancer mutations disrupt this process.

bioRxiv · Feb 23, 2023Biochemistry

A giant virus genome is densely packaged by stable nucleosomes within virions

T. D. Bryson, P. De Ioannes, M. I. Valencia-Sanchez, J. G. Henikoff, P. B. Talbert, B. La Scola, K.-J. Armache, S. Henikoff

The paper shows that Marseillevirus uses fully wrapped nucleosomes to densely package its genome, differing from eukaryotic chromatin organization.

bioRxiv · Jan 15, 2022Evolutionary Biology

RNA strand invasion activity of the Polycomb complex PRC2

C. Alecki, V. Chiwara, L. A. Sanz, D. Grau, O. Arias Perez, K.-J. Armache, F. Chedin, N. J. Francis

The paper identifies RNA strand invasion activity by PRC2 that drives R-loop formation at PREs, linking non-canonical nucleic acid structures to epigenetic regulation.

bioRxiv · May 15, 2019Biochemistry

Distinct stimulatory mechanisms regulate the catalytic activity of Polycomb Repressive Complex 2 (PRC2)

C.-H. Lee, M. Holder, D. Grau, R. Saldana-Meyer, R. A. Ganai, J. Zhang, M. Wang, M.-W. Dobenecker, D. Reinberg, K.-J. Armache

The paper shows that EZH1 and EZH2, two catalytic subunits of PRC2, are differentially activated to regulate H3K27 methylation, with AEBP2 adding additional stimulation.

bioRxiv · Nov 3, 2017Biochemistry