Author

R. Adafia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

M. M. Stratton· 2 shared A. E. Langkilde· 1 shared A. S. G. Larsen· 1 shared A. Samkutty· 1 shared A. T. Ocampo· 1 shared B. Frolund· 1 shared C. L. Gee· 1 shared C. Ozden· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiophysics

M. M. Stratton

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2 papers

Recent·Most cited

Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking and kinase inhibition

D. Narayanan, A. S. G. Larsen, S. J. Gauger, R. Adafia, R. B. Hammershoi, L. Hamborg, J. Bruus-Jensen, N. Griem-Krey, C. L. Gee, B. Frolund, M. M. Stratton, J. Kuriyan, J. S. Kastrup, A. E. Langkilde, P. Wellendorph, S. M. O. Solbak

This paper investigates how PIPA, a GHB analog, affects CaMKII hub domain conformation and stability, revealing a mechanism involving Trp403 flip and hub domain stacking that reduces kinase activity.

bioRxiv · Mar 26, 2024 · PreprintBiophysics

CaMKIIalpha and CaMKIIbeta hub domains adopt distinct oligomeric states and stabilities

C. Ozden, S. MacManus, R. Adafia, A. Samkutty, A. T. Ocampo, S. C. Garman, M. M. Stratton

This study investigates the oligomeric states and stability of CaMKIIalpha and CaMKIIbeta hub domains, revealing differences in their stoichiometry and stability in solution.

bioRxiv · Oct 9, 2023 · PreprintBiochemistry