Author

A. E. Langkilde

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Approach:Bayesian inference· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

B. B. Kragelund· 2 shared E. A. Newcombe· 2 shared A. Jussupow· 1 shared A. Kowalski· 1 shared A. S. G. Larsen· 1 shared B. Frolund· 1 shared C. Betzer· 1 shared C. Camilloni· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

B. B. Kragelund

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking and kinase inhibition

D. Narayanan, A. S. G. Larsen, S. J. Gauger, R. Adafia, R. B. Hammershoi, L. Hamborg, J. Bruus-Jensen, N. Griem-Krey, C. L. Gee, B. Frolund, M. M. Stratton, J. Kuriyan, J. S. Kastrup, A. E. Langkilde, P. Wellendorph, S. M. O. Solbak

This paper investigates how PIPA, a GHB analog, affects CaMKII hub domain conformation and stability, revealing a mechanism involving Trp403 flip and hub domain stacking that reduces kinase activity.

bioRxiv · Mar 26, 2024 · PreprintBiophysics

Monomeric α-Synuclein activates the Plasma Membrane Calcium Pump

A. Kowalski, C. Betzer, S. T. Larsen, E. Gregersen, E. A. Newcombe, M. C. Bermejo, A. E. Langkilde, B. B. Kragelund, P. H. Jensen, P. Nissen

This study shows that monomeric α-synuclein activates the plasma membrane calcium pump (PMCA) in neurons, enhancing calcium expulsion through interactions with acidic phospholipids and membrane anchoring.

bioRxiv · Feb 21, 2022Biochemistry

Refinement of α-synuclein ensembles against SAXS data: Comparison of force fields and methods

M. C. Ahmed, L. K. Skaanning, A. Jussupow, E. A. Newcombe, B. B. Kragelund, C. Camilloni, A. E. Langkilde, K. Lindorff-Larsen

The paper compares force fields and methods for refining α-synuclein ensembles using SAXS data, showing that accurate ensembles require compatible simulations and experimental integration.

bioRxiv · Jan 15, 2021Biophysics