Author

M. M. Stratton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

R. Adafia· 2 shared A. C. Chueh· 1 shared A. E. Langkilde· 1 shared A. M. Ellisdon· 1 shared A. Martinez· 1 shared A. P. Torres-Ocampo· 1 shared A. S. G. Larsen· 1 shared A. Samkutty· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBiophysics

R. Adafia

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking and kinase inhibition

D. Narayanan, A. S. G. Larsen, S. J. Gauger, R. Adafia, R. B. Hammershoi, L. Hamborg, J. Bruus-Jensen, N. Griem-Krey, C. L. Gee, B. Frolund, M. M. Stratton, J. Kuriyan, J. S. Kastrup, A. E. Langkilde, P. Wellendorph, S. M. O. Solbak

This paper investigates how PIPA, a GHB analog, affects CaMKII hub domain conformation and stability, revealing a mechanism involving Trp403 flip and hub domain stacking that reduces kinase activity.

bioRxiv · Mar 26, 2024 · PreprintBiophysics

Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically "actionable" signalling axis in triple negative breast cancer

X. Yang, X. Ma, T. Zhao, D. R. Croucher, E. V. Nguyen, K. C. Clark, C. Hu, S. L. Latham, C. Bayly-Jones, V. C. B. Nguyen, S. Budnar, S. Shin, L. K. Nguyen, T. R. Cotton, A. C. Chueh, , R. J. Daly

This study identifies a novel feed-forward signalling axis between PEAK1 and CAMK2 in TNBC, showing that targeting CAMK2 can inhibit PEAK1-driven oncogenic processes.

bioRxiv · Feb 14, 2024Cancer Biology

CaMKIIalpha and CaMKIIbeta hub domains adopt distinct oligomeric states and stabilities

C. Ozden, S. MacManus, R. Adafia, A. Samkutty, A. T. Ocampo, S. C. Garman, M. M. Stratton

This study investigates the oligomeric states and stability of CaMKIIalpha and CaMKIIbeta hub domains, revealing differences in their stoichiometry and stability in solution.

bioRxiv · Oct 9, 2023 · PreprintBiochemistry

Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation

R. Sloutsky, N. Dziedzic, M. J. Dunn, R. Bates, A. P. Torres-Ocampo, S. Boopathy, B. Page, J. G. Weeks, L. H. Chao, M. M. Stratton

The paper identifies 70 CaMKII transcripts in human hippocampus and shows that the hub domain regulates kinase activity through allosteric interactions.

bioRxiv · Jan 10, 2020Biochemistry

Molecular determinants of Arc oligomerization and formation of virus-like capsids

M. S. Eriksen, O. Nikolaienko, E. I. Hallin, S. Grodem, H. J. Bustad, M. I. Flydal, R. O'Connell, T. Hosokawa, D. Lascu, S. Akerkar, J. Cuellar, J. J. Chambers, I. Merski, G. Muruganandam, R. Loris, , C. R. Bramham

This paper identifies a 28-amino-acid region in Arc critical for oligomerization and virus-like capsid formation, showing that exogenous RNA enhances assembly.

bioRxiv · Nov 22, 2019 · PreprintBiochemistry

Development of a genetically encoded sensor for endogenous CaMKII activity

G. Ardestani, M. West, T. J. Maresca, R. A. Fissore, M. M. Stratton

The paper develops a genetically encoded sensor, FRESCA, for measuring endogenous CaMKII activity, showing it captures aggregate activity across multiple variants unlike existing sensors.

bioRxiv · Nov 9, 2018 · PreprintBiochemistry