Author

N. Griem-Krey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

P. Wellendorph· 3 shared A. B. Klein· 2 shared A. N. Clarkson· 2 shared A. S. G. Larsen· 2 shared B. Frolund· 2 shared C. L. Gee· 2 shared J. Kuriyan· 2 shared L. Hamborg· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiophysics

P. Wellendorph

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking and kinase inhibition

D. Narayanan, A. S. G. Larsen, S. J. Gauger, R. Adafia, R. B. Hammershoi, L. Hamborg, J. Bruus-Jensen, N. Griem-Krey, C. L. Gee, B. Frolund, M. M. Stratton, J. Kuriyan, J. S. Kastrup, A. E. Langkilde, P. Wellendorph, S. M. O. Solbak

This paper investigates how PIPA, a GHB analog, affects CaMKII hub domain conformation and stability, revealing a mechanism involving Trp403 flip and hub domain stacking that reduces kinase activity.

bioRxiv · Mar 26, 2024 · PreprintBiophysics

The GHB analogue HOCPCA improves sensorimotor function after MCAO via CaMKIIα

N. Griem-Krey, A. B. Klein, B. H. Clausen, M. R. Namini, P. V. Nielsen, H. Chin-Cheng, C. Orset, D. Vivien, A. N. Clarkson, K. L. Lambertsen, P. Wellendorph

The paper shows HOCPCA, a GHB ligand, improves sensorimotor function after stroke in mice by modulating CaMKII signaling and reducing aberrant activity.

bioRxiv · Mar 10, 2022 · PreprintPharmacology & Toxicology

GHB confers neuroprotection by stabilizing the CaMKIIα hub domain

U. Leurs, A. B. Klein, E. D. McSpadden, N. Griem-Krey, S. M. Solbak, J. Houlton, I. S. Villumsen, S. B. Vogensen, L. Hamborg, S. J. Gauger, L. B. Palmelund, A. S. G. Larsen, M. A. Shehata, C. D. Kelstrup, J. V. Olsen, , P. Wellendorph

This study shows that GHB stabilizes the CaMKII hub domain, providing neuroprotection in cellular and mouse models.

bioRxiv · Sep 28, 2020 · PreprintBiochemistry