Degradation of Alzheimers Amyloid-beta by a Catalytically Inactive Insulin Degrading Enzyme
B. Sahoo, P. K. Panda, W. Liang, W.-J. Tang, R. Ahuja, A. Ramamoorthy
This study shows that a catalytically inactive insulin-degrading enzyme variant can degrade Alzheimer's amyloid-beta via a non-chaperone mechanism, with zinc binding inactivating its function.
bioRxiv · Apr 23, 2020Biophysics