W. Liang

Differential antigenic imprinting effects between influenza H1N1 hemagglutinin and neuraminidase in a mouse model

This study examines how immune history affects antibody responses to influenza H1N1 hemagglutinin and neuraminidase in mice, finding that HA responses are more restricted by prior infection than NA responses.

Cervical collagen network porosity assessed by SHG endomicroscopy distinguishes preterm and normal pregnancy - a pilot study

The J-Like Protein ARC6 Regulates Chloroplast FtsZ-Ring Assembly through Fine-tuning ARC3 Activity in Arabidopsis

The paper identifies ARC6 as a regulator of chloroplast division by modulating ARC3 activity through its J-like domain, ensuring proper Z-ring assembly and positioning.

Long noncoding RNA Hottip maintained skeletal homeostasis via suppressing the enhancer of zeste homolog 2 (Ezh2)/histone methylation regulatory axis

This study identifies Hottip as a regulator of skeletal homeostasis by suppressing the Ezh2/histone methylation axis, affecting osteoblast and osteoclast differentiation.

An axonemal intron splicing program sustains Plasmodium male development

This study identifies RBPm1 as a splicing activator essential for axoneme assembly in Plasmodium male gametogenesis, revealing an intron splicing program critical for male development.

Predictive evolutionary modelling for influenza virus by site-based dynamics of mutations

A computational model predicts influenza virus evolution and aids in vaccine strain selection by modeling site-wise mutation dynamics.

Slow conduction and spatial dispersion of repolarization are intrinsic properties of cardiomyocyte electrophysiology that contribute to proarrhythmia in an iPSC model of hypertrophic cardiomyopathy

This study shows that HCM cardiomyocytes have slower conduction and increased repolarization dispersion, which contribute to arrhythmia in an iPSC model.

Identification of a novel MCR-1 variant displaying low level of co-resistance to β-lactam antibiotics that uncovers a potential novel antimicrobial peptide

The paper identifies a novel MCR-1 variant with low β-lactam co-resistance and shows synthetic peptides from this variant have broad-spectrum antimicrobial activity.

Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer

The paper shows that secondary bile acids from gut bacteria worsen colorectal cancer in a Western diet model.

The Small GTPase Rab7 Regulates Release of Mitochondria in Extracellular Vesicles in Response to Lysosomal Dysfunction

The paper shows that Rab7 regulates mitochondrial release in extracellular vesicles when lysosomal function is impaired, and this process occurs in cardiac pathophysiology.

Lack of neutralizing antibodies against the current circulating influenza viruses during the Omicron outbreak in Hong Kong

The paper reports low neutralizing antibody levels against influenza A H1N1 and H3N2 viruses in adults during the Omicron outbreak, emphasizing the need for influenza vaccination.

Complexes Formed by Mixing Tumor-derived Extracellular Vesicles with Polymeric Surfactants for Personalized Therapeutic Vaccine

This paper develops a therapeutic vaccine using tumor-derived extracellular vesicles modified with polymeric surfactants to enhance immunogenicity and efficacy against melanoma.

Vascular endothelial growth factor A contributes to the increasing of mammalian respiratory epithelial permeability induced by Pasteurella multocida infection

This study shows that P. multocida infection increases respiratory epithelial permeability in mice and humans by activating the HIF-1 and VEGFA signaling pathways.

Acetylation of a fungal effector that translocates host PR1 facilitates virulence

This study identifies acetylation of the fungal effector FolSvp1 as critical for its stability and virulence in tomato plants.

Age-related seroprevalence trajectories of seasonal coronaviruses in children

This study examines age-related seroprevalence of four seasonal coronaviruses in children and postpartum women, showing waning passive immunity and resurgence of IgGs with age.

A translational swine model for Crohn`s disease

This paper develops a genome-edited swine model of Crohn's disease that replicates key human disease features to enable translational research.

Sex differences in the nasal microbiome of healthy young adults

This study analyzes the nasal microbiome of healthy young adults, revealing sex-specific differences in composition and ecological stability between males and females.

Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes

This study shows that loss of Ash2l in mouse fibroblasts reduces H3K4 methylation and gene expression, leading to senescence independent of SASP, with FoxM1-responsive genes involved.

Egg-adaptation pathway of human influenza H3N2 virus is contingent on natural evolution

The paper shows that natural mutations in human H3N2 HA influence the egg-adaptation pathway, affecting mutation emergence during vaccine production.

The decrotonylase FoSir5 facilitates mitochondrial metabolic state switching in conidial germination of Fusarium oxysporum

The paper shows that FoSir5 decrotonylates key targets to regulate metabolic state switching during conidial germination in Fusarium oxysporum.

Parapatric speciation with recurrent gene flow of two sexual dichromatic pheasants

This study shows that two pheasant species have experienced recurrent gene flow during speciation, with evidence of long-term gene flow after initial divergence and ongoing contact in recent times.

Profiling tumor immune microenvironment of non-small cell lung cancer using multiplex immunofluorescence

This study profiles the tumor immune microenvironment of NSCLC using multiplex immunofluorescence, identifying three immune subtypes and an immune-related risk score for prognosis prediction.

Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents

This study analyzes evolutionary changes in Cdx2's DNA binding and transcriptional regulation between mice and rats, finding conserved transcriptional output despite divergent DNA binding.

Homologous and heterologous serological response to the N-terminal domain of SARS-CoV-2

The paper examines the serological response to the N-terminal domain (NTD) of SARS-CoV-2, showing it is less cross-reactive with SARS-CoV and less effective as an immunogen compared to the RBD.

A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaques

Degradation of Alzheimers Amyloid-beta by a Catalytically Inactive Insulin Degrading Enzyme

This study shows that a catalytically inactive insulin-degrading enzyme variant can degrade Alzheimer's amyloid-beta via a non-chaperone mechanism, with zinc binding inactivating its function.

Dynamics of mcr-1 prevalence and mcr-1-positive Escherichia coli after the cessation of colistin use as a feed additive for animals in China: a prospective cross-sectional and whole genome sequencing based molecular epidemiological study

This study tracks the decline of mcr-1 prevalence and genetic changes in mcr-1-positive Escherichia coli after China banned colistin use in animal feed.

Estimating invasion dynamics with geopolitical-unit level records: performance and similarity of common methods using both simulated data and a real case

This paper evaluates eight methods for estimating invasion dynamics using geopolitical-unit data, finds CEB and regression methods perform best, and shows boundary displacement methods are most accurate for spread rates and dynamics.

Migratory divides coincide with species barriers across replicated avian hybrid zones above the Tibetan Plateau

The paper examines reproductive isolation in barn swallow subspecies pairs, finding strong isolation coincides with migratory divides across the Tibetan Plateau, supporting the role of migratory behavior in speciation.

Characterization and repurposing of the endogenous Type I-F CRISPR-Cas system of Zymomonas mobilis for genome engineering

This study characterizes and repurposes the endogenous Type I-F CRISPR-Cas system of Zymomonas mobilis to create an efficient genome engineering toolkit with 100% efficiency in various genetic modifications.