R. Aljuhani

Galectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatse Sulf-2

This study identifies LG3BP as a binding partner of Sulf-2 in HNSCC and shows that LG3BP inhibits Sulf-2 activity, reducing HNSCC cell invasion.

Heparan-6-O-endosulfatase 2 promotes invasiveness of head and neck squamous carcinoma cell lines in co-cultures with cancer associated fibroblasts

This study shows that Sulf-2 promotes HNSCC cell invasion in co-cultures with CAFs, and a marine glycosaminoglycan inhibits this effect.