The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice lightsheet microscopy
S. E. Quinn, L. Huang, J. G. Kerkvliet, J. A. Swanson, S. Smith, A. D. Hoppe, R. B. Anderson, N. W. Thiex, B. L. Scott
This study uses lattice lightsheet microscopy to show that PI3K activity is critical for sealing ruffles into macropinosomes, but not for regulating their morphology.
bioRxiv · Dec 1, 2020Cell Biology