J. G. Kerkvliet

This study shows that sterols reduce the energy required for membrane bending and fission during clathrin-mediated endocytosis, and that their depletion impairs this process and affects cellular function.

This study uses lattice lightsheet microscopy to show that PI3K activity is critical for sealing ruffles into macropinosomes, but not for regulating their morphology.

The paper uses advanced imaging techniques to study membrane bending during clathrin-coat assembly and finds that bending occurs at different stages of the process, challenging existing models.