Targeting Ribosome Biogenesis as a Novel Therapeutic Approach to Overcome EMT-related Chemoresistance in Breast Cancer.
Y. Ban, Y. Zou, Y. Liu, S. B. Lee, R. B. Bednarczyk, J. Sheng, Y. Cao, S. T. C. Wong, D. Gao
This study identifies ribosome biogenesis as a key driver of EMT/MET transitions in breast cancer and shows that targeting this pathway enhances chemotherapy efficacy against chemoresistant tumors.
bioRxiv · Jun 28, 2023Cancer Biology