Author

R. Begum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Bioengineering· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

A. Woolston· 2 shared D. Cunningham· 2 shared I. Chau· 2 shared K. von Loga· 2 shared L. J. Barber· 2 shared M. Gerlinger· 2 shared N. Parmar· 2 shared N. Rathwa· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

A. Woolston

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Genetic and immune landscape evolution defines subtypes of MMR deficient colorectal cancer

B. R. Challoner, A. Woolston, D. Lau, M. Buzzetti, C. Fong, L. J. Barber, G. Anandappa, R. Crux, I. Assiotis, K. Fenwick, R. Begum, D. Begum, T. Lund, N. Sivamanoharan, H. B. Sansano, , M. Gerlinger

The paper identifies three subtypes of MMR deficient colorectal cancer based on genetic and immune landscape evolution, linking them to T-cell infiltrates and checkpoint-inhibitor resistance.

bioRxiv · Feb 16, 2022 · PreprintCancer Biology

Calorie Restriction in combination with GABA: improved glycaemic control in type 2 diabetes mouse model

N. Rathwa, N. Parmar, S. Pramanik Palit, R. Patel, R. Shankar Bhaskaran, A. V. Ramachandran, R. Begum

This study shows that combining calorie restriction with GABA improves glycemic control and beta-cell regeneration in a T2D mouse model.

bioRxiv · May 12, 2021 · PreprintPhysiology

Repurposing statin and L-glutamine: replenishing β-cells in hyperlipidemic T2D mouse model

S. Pramanik Palit, R. Patel, N. Parmar, N. Rathwa, N. Dalvi, R. Menon, R. Begum

This study investigates the combined effect of pitavastatin and L-glutamine on glycemic control and β-cell regeneration in a T2D mouse model, finding improved insulin resistance and β-cell regeneration.

bioRxiv · Apr 22, 2021 · PreprintBiochemistry

Antimicrobial Resistance Profile and mcr-1 gene Detection in Salmonella Isolates from Poultry in Bangladesh: Molecular and Bioinformatics Characterization

M. B. Uddin, S. B. Hossain, M. Hasan, M. N. Alam, M. Debnath, R. Begum, S. Roy, A. Harun-Al-Rashid, M. S. R. Chowdhury, M. M. Rahman, M. M. Hossain, M. Y. E. Chowdhury, S. S. U. Ahmed

The paper detects the mcr-1 gene in Salmonella isolates from poultry in Bangladesh using PCR and bioinformatics analysis, revealing colistin resistance mechanisms.

bioRxiv · Mar 27, 2020 · PreprintMicrobiology

Genomic and transcriptomic determinants of therapy resistance and immune landscape evolution during anti-EGFR treatment in colorectal cancer

A. Woolston, K. Khan, G. Spain, L. J. Barber, B. Griffiths, R. Gonzalez Exposito, Y. Patil, S. Mansukhani, M. N. Davies, A. Furness, F. Sclafani, C. Peckitt, K. Kouvelakis, R. Ranftl, R. Begum, , M. Gerlinger

The paper analyzes genomic and transcriptomic data from CRC patients treated with cetuximab to identify resistance mechanisms and immune landscape changes during anti-EGFR therapy.

bioRxiv · Oct 19, 2018Cancer Biology

Electrospun Cellulose-Silk Composite Nanofibres Direct Mesenchymal Stem Cell Chondrogenesis in the Absence of Biological Stimulation

R. Begum, B. Su, A. Perriman, F. Scarpa, W. Kafienah

This paper develops electrospun cellulose-silk composite nanofibers that direct chondrogenic differentiation of hMSCs without growth factors.

bioRxiv · Oct 3, 2018 · PreprintBioengineering