N. Parmar

Postnatal intestinal epithelial maturation by LSD1 controls the small intestinal immune cell composition independently from the microbiota

This study shows that LSD1 in intestinal epithelial cells controls immune cell composition postnatally, independent of microbiota.

Mmp17-deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection

This study shows that Mmp17-deficient mice have increased goblet cell effector genes and resistance to Trichuris muris infection without changes in traditional immune modulators.

Separate Gut Plasma Cell Populations Produce Autoantibodies Against Transglutaminase 2 and Transglutaminase 3 in Dermatitis Herpetiformis

The paper identifies separate gut plasma cell populations in DH patients producing autoantibodies specific to TG2 and TG3 with no cross-reactivity.

Chronic industrial perturbation and seasonal change induces shift in the bacterial community from gammaproteobacteria to betaproteobacteria at Amlakhadi canal

The study examines seasonal shifts in bacterial communities at Amlakhadi canal, showing a shift from Gammaproteobacteria to Betaproteobacteria in response to industrial pollution and seasonal changes.

Calorie Restriction in combination with GABA: improved glycaemic control in type 2 diabetes mouse model

This study shows that combining calorie restriction with GABA improves glycemic control and beta-cell regeneration in a T2D mouse model.

Repurposing statin and L-glutamine: replenishing β-cells in hyperlipidemic T2D mouse model

This study investigates the combined effect of pitavastatin and L-glutamine on glycemic control and β-cell regeneration in a T2D mouse model, finding improved insulin resistance and β-cell regeneration.

A semi-automated intestinal organoid screening method demonstrates epigenetic control of epithelial differentiation

This study develops a semi-automated intestinal organoid screening method to identify epigenetic regulators of epithelial differentiation, finding that inhibiting type I PRMTs enhances differentiation and blocks adenoma growth.

Developmental pathways regulate cytokine-driven effector and feedback responses in the intestinal epithelium

The paper investigates how cytokines regulate intestinal epithelial responses through developmental pathways, showing IL-13 induces goblet cells via NOTCH signaling and uses BMP signaling as a feedback loop in tuft cell hyperplasia.