Cancer BiologybioRxiv
Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS/AML
E. C. Wheeler, B. J. E. Martin, W. C. Doyle…·Z. Tothova
The paper shows SF3B1 splicing modulators impair DNA damage response in cohesin-mutant MDS/AML, leading to increased sensitivity to PARP inhibitors and chemotherapy.
DOI 10.1126/scitranslmed.ade2774