Author

R. C. Lynn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. L. Mackall· 2 shared E. Sotillo· 2 shared E. W. Weber· 2 shared H. Anbunathan· 2 shared P. Xu· 2 shared Z. Good· 2 shared A. J. Gentles· 1 shared A. Satpathy· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

C. L. Mackall

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Transient "rest" induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells

E. W. Weber, R. C. Lynn, K. R. Parker, H. Anbunathan, J. Lattin, E. Sotillo, Z. Good, M. Malipatlolla, P. Xu, P. Vandris, R. G. Majzner, Y. Qi, L.-C. Chen, A. J. Gentles, T. J. Wandless, , C. L. Mackall

This study shows that temporarily stopping CAR-T cell signaling can reverse exhaustion and improve their anti-tumor function through transcriptional and epigenetic changes.

bioRxiv · Jan 26, 2020 · PreprintImmunology

c-Jun Overexpressing CAR-T Cells are Exhaustion-Resistant and Mediate Enhanced Antitumor Activity

R. C. Lynn, E. W. Weber, D. Gennert, E. Sotillo, P. Xu, Z. Good, H. Anbunathan, R. Jones, V. Tieu, J. Granja, C. DeBourcy, R. Majzner, A. Satpathy, S. R. Quake, H. Chang, C. L. Mackall

This study shows that overexpressing c-Jun in CAR-T cells reduces exhaustion and improves antitumor activity in vivo.

bioRxiv · May 29, 2019 · PreprintImmunology