Author

K. R. Parker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:CITE-seq· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

H. Y. Chang· 4 shared Y. Qi· 3 shared A. T. Satpathy· 2 shared A. J. Gentles· 1 shared A. Limaye· 1 shared A. N. Boettiger· 1 shared A. Satpathy· 1 shared A. Y. Ting· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCell Biology

H. Y. Chang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells

C. A. Tsuchida, N. Brandes, R. Bueno, M. Trinidad, T. Mazumder, B. Yu, B. Hwang, C. Chang, J. Liu, Y. Sun, C. R. Hopkins, K. R. Parker, Y. Qi, A. Satpathy, E. Stadtmauer, , J. A. Doudna

This study investigates chromosome loss in CRISPR-Cas9-engineered T cells and shows a modified manufacturing process reduces it while preserving editing efficacy.

bioRxiv · Mar 22, 2023Cell Biology

Systematic discovery and functional interrogation of SARS-CoV-2 viral RNA-host protein interactions during infection

R. A. Flynn, J. A. Belk, Y. Qi, Y. Yasumoto, C. O. Schmitz, M. R. Mumbach, A. Limaye, J. Wei, M. M. Alfajaro, K. R. Parker, H. Y. Chang, T. L. Horvath, J. E. Carette, C. Bertozzi, C. B. Wilen, A. T. Satpathy

This study identifies 309 host proteins interacting with SARS-CoV-2 RNA during infection and reveals their roles in virus-induced cell death and mitochondrial dysfunction.

bioRxiv · Oct 6, 2020 · PreprintMicrobiology

Transient "rest" induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells

E. W. Weber, R. C. Lynn, K. R. Parker, H. Anbunathan, J. Lattin, E. Sotillo, Z. Good, M. Malipatlolla, P. Xu, P. Vandris, R. G. Majzner, Y. Qi, L.-C. Chen, A. J. Gentles, T. J. Wandless, , C. L. Mackall

This study shows that temporarily stopping CAR-T cell signaling can reverse exhaustion and improve their anti-tumor function through transcriptional and epigenetic changes.

bioRxiv · Jan 26, 2020 · PreprintImmunology

Atlas of Subcellular RNA Localization Revealed by APEX-seq

F. M. Fazal, S. Han, P. Kaewsapsak, K. R. Parker, J. Xu, A. N. Boettiger, H. Y. Chang, A. Y. Ting

APEX-seq maps subcellular RNA localization with nanometer resolution, revealing nuclear transcriptome organization and mitochondrial mRNA pathways.

Cell · Jul 1, 2019Peer-reviewedCell Biology