Author

A. J. Gentles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Azizi· 1 shared A. Bejnood· 1 shared A. Hui· 1 shared A. Kuong· 1 shared A. P. Boss· 1 shared A. T. Satpathy· 1 shared A. Yu· 1 shared A.-M. Cepika· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperCancer Biology

A. Azizi

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Author profile →

3 papers

Recent·Most cited

AML/T cell interactomics uncover correlates of patient outcomes and the key role of ICAM1 in T cell killing of AML

E. C. Sayitoglu, B. A. Luca, A. P. Boss, B. C. Thomas, R. A. Freeborn, M. J. Uyeda, P. P. Chen, Y. Nakauchi, C. Waichler, N. J. Lacayo, R. Bacchetta, R. Majeti, A. J. Gentles, A.-M. Cepika, M. G. Roncarolo

The paper identifies ICAM1 as a key factor in T cell killing of AML by analyzing transcriptional programs in AML and T cell interactions.

bioRxiv · Sep 21, 2023Immunology

Transient "rest" induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells

E. W. Weber, R. C. Lynn, K. R. Parker, H. Anbunathan, J. Lattin, E. Sotillo, Z. Good, M. Malipatlolla, P. Xu, P. Vandris, R. G. Majzner, Y. Qi, L.-C. Chen, A. J. Gentles, T. J. Wandless, , C. L. Mackall

This study shows that temporarily stopping CAR-T cell signaling can reverse exhaustion and improve their anti-tumor function through transcriptional and epigenetic changes.

bioRxiv · Jan 26, 2020 · PreprintImmunology

Clinically-relevant cell type cross-talk identified from a human lung tumor microenvironment interactome

A. J. Gentles, A. Hui, W. Feng, A. Azizi, R. Nair, D. Knowles, A. Yu, Y. Jeong, A. Bejnood, E. Forgo, S. Varma, Y. Xu, A. Kuong, V. Nair, R. West, , S. Plevritis

The paper identifies clinically relevant cell type interactions in the lung tumor microenvironment using RNA-seq data from sorted cell populations.

bioRxiv · May 30, 2019 · PreprintCancer Biology